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If the allodynia is severe enough to significantly impair quality of life, temporary discontinuation allows the nervous system to reset

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Advantages of 503B Facilities: Direct FDA oversight cGMP requirements (same as drug manufacturers) Regular FDA inspections Mandatory adverse event reporting Can produce larger batches How to Verify: Visit the FDA website and search registered outsourcing facilities to confirm the pharmacy is listed and in good standing

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The objective of this review is to critically assess the current evidence surrounding their mechanisms of action, clinical indications, efficacy, and safety profiles, with particular emphasis on regulatory and translational considerations